Lanthanide-based Nanoparticles for Multimodal Molecular Imaging and Targeted Alpha Therapy

Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy

Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is c...

Nanotechnology for molecular imaging and targeted therapy.

The recent emergence of “molecular imaging” as an integrated discipline in academic medical centers has set the stage for an evolutionary leap in diagnostic imaging and therapy.1 Molecular imaging is not a substitute for the traditional process of image formation and interpretation, but is intended to improve diagnostic accuracy and sensitivity by providing an in vivo analog of immunocytochemis...

Targeted Multimodal Liposomes for Imaging and Radionuclide Therapy

GERBEN A. KONING*, WILLEM MULDER, GUSTAV J. STRIJKERS, KLAAS NICOLAY, SANDER ZIELHUIS, FRANK NIJSEN, MARJAN M. FRETZ, GERT STORM and GERARD C. KRIJGER Department of Radiation, Radioisotopes and Reactors, Delft University of Technology, Mekelweg 15, 2629-JB, Delft, The Netherlands, Department of Biomedical NMR, Eindhoven University of Technology, The Netherlands, Department of Nuclear Medicine, ...

Core/Shell structured nanoparticles for imaging and therapy

Introduction: Nanoparticles have several exciting applications in various fields of biomedicine. It has been found that among different classes of nanoparticles core/shell is most promising for field of nano-medical imaging and therapy due to their distinct advantages. The core/shell type nanoparticles can be generally comprising of two nanoparticles one act as a core (inner ma...

Antibody Targeted Nanoparticles for Imaging and Therapy of Cancer